2022
Ishihara, Keisuke; Mukherjee, Arghyadip; Gromberg, Elena; Brugués, Jan; Tanaka, Elly M.; Jülicher, Frank. Topological morphogenesis of neuroepithelial organoids. Nature Physics https://doi.org/10.1038/s41567-022-01822-6 (2022)
Research Briefing by Nature Physics: https://doi.org/10.1038/s41567-022-01843-1
Riquelme-Guzmán, Camilo; Tsai, Stephanie L.; Carreon Paz, Karen; Nguyen, Congtin; Oriola, David; Schuez, Maritta; Brugués, Jan; Currie, Joshua D.; Sandoval-Guzmán, Tatiana. Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration. Elife https://doi.org/10.7554/eLife.79966 (2022)
Dalton, Benjamin A.; Oriola, David; Decker, Franziska; Jülicher, Frank; Brugués, Jan. A gelation transition enables the self-organization of bipolar metaphase spindles. Nature Physics, https://doi.org/10.5281/zenodo.4618598 (2022)
2021
Quail, Thomas; Golfier, Stefan; Elsner, Maria; Ishihara, Keisuke; Renger, Roman; Jülicher, Frank; Brugués, Jan. Force generation by protein-DNA co-condensation. Nature Physics, https://doi.org/10.1038/s41567-021-01285-1 (2021)
Research highlight by Nature Physics: https://www.nature.com/articles/s41567-021-01286-0
Ishihara, Keisuke; Decker, Franziska; Caldas, Paolo; Pelletier, James F; Loose, Martin; Brugués, Jan; Mitchison, Timothy J. Spatial variation of microtubule depolymerization in large asters suggests regulation by MAP depletion.
Molecular Biology of the Cell, 32(9), 869-879, https://doi.org/10.1091/mbc.E20-11-0723 (2021).
2020
McCall, Patrick; Kim, Kyoohyun; Fritsch, Anatol W; Iglesias-Artola, Juan M; Jawerth, Louise M; Wang, Jie; Ruer, Martine; Peychl, Jan; Poznyakovskiy, Andrey; Guck, Jochen; Alberti, Simon; Hyman, Anthony A; Brugués, Jan. Quantitative phase microscopy enables precise and efficient determination of biomolecular condensate composition.
Biorxiv, https://doi.org/10.1101/2020.10.25.352823 (2020)
Oriola, David; Jülicher, Frank; Brugués, Jan. Active forces shape the metaphase spindle through a mechanical instability. PNAS, https://doi.org/10.1073/pnas.2002446117 (2020).
Rieckhoff, Elisa Maria; Berndt, Frederic; Golfier, Stefan; Decker, Franziska; Elsner, Maria; Ishihara, Keisuke; Brugués, Jan. Spindle scaling is governed by cell boundary regulation of microtubule nucleation.
Current Biology 30, 4973-4983, https://doi.org/10.1016/j.cub.2020.10.093 (2020).
Golfier, Stefan; Quail, Thomas; Kimura, Hiroshi; Brugués, Jan. Cohesin and condensin extrude loops in a cell-cycle dependent manner. Elife 9, e53885 10.7554/eLife.53885 (2020)
Fabig, Gunar; Kiwis, Robert; Lindow, Norbert; Powers, James A; Cota, Vanessa; Quintanilla, Luis J; Brugués, Jan; Prohaska, Steffen; Chu, Diana S; Müller-Reichert, Thomas. Male meiotic spindle features that efficiently segregate paired and lagging chromosomes. Elife 9, e50988 10.7554/eLife.50988 (2020)
2019
Caldas, Paolo; López-Pelegrín, Mar; Pearce, Daniel JG; Burak Budanur, Nazmi; Brugués, Jan; Loose, Martin. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosllinker ZapA. Nature Communications, 10:5744 https://doi.org/10.1038/s41467-019-13702-4 (2019).
Baumgart, Johannes; Kirchner, Marcel; Redemann, Stefanie; Bond, Alec; Woodruff, Jeffrey; Verbavatz, Jean-Marc; Jülicher, Frank; Müller-Reichert, Thomas; Hyman, Anthony A; Brugués, Jan. Soluble tubulin is significantly enriched at mitotic centrosomes. Journal of Cell Biology, 218(12): 3977-3985, https://doi.org/10.1083/jcb.201902069 (2019).
Rieckhoff, Elisa Maria; Ishihara, Keisuke; Brugués, Jan. How to tune spindle size relative to cell size?
Current opinion in cell biology 60, 139-144, (2019).
2018
Oriola, David; Needleman, Daniel J; Brugués, Jan. The physics of the metaphase spindle. Annual review of biophysics 47, 655-673, (2018).
Decker, Franziska; Oriola, David; Dalton, Benjamin; Brugués, Jan. Autocatalytic microtubule nucleation determines the size and mass of Xenopus Laevis egg extract spindles. eLife, 7:e31149, 10.7554/eLife.31149 (2018).
Berndt, Frederic; Shah, Gopi; Brugués, Jan; Huisken, Jan. Dynamic non-contact 3D sample rotation for microscopy. Nature Communications 9: 5025 (2018).
2017
Redemann, Stefanie; Baumgart, Johannes; Lindow, Norbert; Shelley, Michael; Nazockdast, Ehssan; Kratz, Andrea; Prohaska, Steffen; Brugués, Jan; Fürthauer, Sebastian; Müller-Reichert, Thomas. C. elegans chromosomes connect to centrosomes by anchoring into the spindle network.
Nature Communications, 8:15288, https://doi.org/10.1038/ncomms15288 (2017).
Brugués, Jan. Cytoskeleton Dynamics: Mind the Gap! Current Biology, 27 (7): R279-R281, (2017).
2015
Alert, Ricard; Casademunt, Jaume; Brugués*, Jan; Sens*, Pierre. Model for Probing Membrane-Cortex Adhesion by Micropipette Aspiration and Fluctuation Spectroscopy. Biophysical journal 108 (8), 1878-1886 (2015) *Corresponding author PubMed
Decker, Franziska; Brugués, Jan. Dissecting microtubule structures by laser ablation. Methods. Mol Biol, 125, pp. 61-75, (2015) download PDF
2014
Brugues, Jan; Needleman, Daniel. Physical basis of spindle self-organization. Proc Natl Acad Sci U.S.A., 111, no. 52, pp. 18496-18500, (2014) PubMedDownload PDF
Yu, Che-Hang; Langowitz, Noah; Wu, Hai-Yin; Farhadifar, Reza; Brugues, Jan; Yoo, Tae Yeon; Needleman, Daniel. Measuring microtubule polarity in spindles with second-harmonic generation. Biophys J, 106, no. 8, pp. 1578-1587, (2014) PubMedDownload PDF
Needleman, Dan; Brugues, Jan. Determining physical principles of subcellular organization. Dev Cell, 29, no. 2, pp. 135-138, (2014) PubMed
2012
Brugués, Jan; Nuzzo, Valeria; Mazur, Eric; Needleman, Daniel. Nucleation and transport organize microtubules in metaphase spindles.Cell, 149, no. 3, pp. 554-564, (2012)PubMed
Previous publications
Orlandi, Javier G; Blanch-Mercader, Carles; Brugués, Jan; Casademunt, Jaume Cooperativity of self-organized Brownian motors pulling on soft cargoes.Phys Rev E Stat Nonlin Soft Matter Phys, 82, no. 6 Pt 1, pp. 61903-61903, (2010)PubMed
Maugis, Benoît; Brugués, Jan; Nassoy, Pierre; Guillen, Nancy; Sens, Pierre; Amblard, François Dynamic instability of the intracellular pressure drives bleb-based motility.J Cell Sci, 123, no. Pt 22, pp. 3884-3892, (2010)PubMed
Norman, Leann L; Brugués, Jan; Sengupta, Kheya; Sens, Pierre; Aranda-Espinoza, Helim Cell blebbing and membrane area homeostasis in spreading and retracting cells.Biophys J, 99, no. 6, pp. 1726-1733, (2010)PubMed
Brugués, Jan; Maugis, Benoît; Casademunt, Jaume; Nassoy, Pierre; Amblard, François; Sens, Pierre Dynamical organization of the cytoskeletal cortex probed by micropipette aspiration.Proc Natl Acad Sci U.S.A., 107, no. 35, pp. 15415-15420, (2010)PubMed
Brugués, Jan; Needleman, Daniel Nonequilibrium fluctuations in metaphase spindles: polarized light microscopy, image registration, and correlation functions Proc SPIE, 7618, (2010)
Brugués, Jan; Casademunt, Jaume Self-organization and cooperativity of weakly coupled molecular motors under unequal loading. Phys Rev Lett, 102, no. 11, pp. 118104-118104, (2009)PubMed
Brugués, Jan; Ignés-Mullol, Jordi; Casademunt, Jaume; Sagués, Francesc Probing elastic anisotropy from defect dynamics in Langmuir monolayers.Phys Rev Lett, 100, no. 3, pp. 37801-37801, (2008)PubMed
Brugués, Jan; Gomis, Joaquim; Kamimura, Kiyoshi Newton-Hooke algebras, nonrelativistic branes, and generalized pp-wave metricsPhysical Review D, 73, no. 8, (2006)
Brugués, Jan; Rojo, Joan; Russo, Jorge G. Nonperturbative states in type II superstring theory from classical spinning membranesNucl Phys B, 710, no. 1-2, pp. 117-138, (2005)
Brugués, Jan; Curtright, Thomas ; Gomis, Joaquim; Mezincescu, Luca Non-relativistic strings and branes as non-linear realizations of Galilei groupsPhys Lett B, 594, no. 1-2, pp. 227-233, (2004)
Brugués, Jan; Gomis, Joaquim; Mateos, T.; Ramirez, T.Commutative and noncommutative= 2 SYM in (2+ 1) from wrapped D6-branesClassical And Quantum Gravity, 20, (2003)
Brugués, Jan; Gomis, Joaquim; Mateos, T.; Ramirez, T. Supergravity Duals of Noncommutative Wrapped D6 Branes and Supersymmetry without SupersymmetryJ High Energy Phys, 2002, (2002)
Brugués Lab 